Peptide receptor radionuclide therapy using radiolabeled somatostatin analogs: focus on future developments
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چکیده
منابع مشابه
Peptide receptor radionuclide therapy using radiolabeled somatostatin analogs: focus on future developments
Peptide receptor radionuclide therapy (PRRT) has been shown to be an effective treatment for neuroendocrine tumors (NETs) if curative surgery is not an option. A majority of NETs abundantly express somatostatin receptors. Consequently, following administration of somatostatin (SST) analogs labeled with γ-emitting radionuclides, these tumors can be imaged for diagnosis, staging or follow-up purp...
متن کاملOverview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs.
A new treatment modality for inoperable or metastasized gastroenteropancreatic tumors is the use of radiolabeled somatostatin analogs. Initial studies with high doses of [(111)In-diethylenetriaminepentaacetic acid (DTPA)(0)]octreotide in patients with metastasized neuroendocrine tumors were encouraging, although partial remissions were uncommon. Another radiolabeled somatostatin analog that is ...
متن کاملENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: peptide receptor radionuclide therapy with radiolabeled somatostatin analogs.
The purpose of this guideline is to assist physicians caring for patients with neuroendocrine tumors in considering eligibility criteria for peptide receptor radionuclide therapy (PRRT), and in defining the minimum requirements for PRRT. This guideline also makes recommendations on what minimal patient, tumor, and treatment outcome characteristics should be reported for PRRT in order to make co...
متن کاملSelection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy.
UNLABELLED The gastrin/cholecystokinin-2 (CCK-2) receptor has been identified as a possible target for peptide receptor radionuclide imaging and therapy. Several radiolabeled peptides binding to this receptor have been explored in animal models and clinical trials but either low tumor uptake or high renal retention has been found. The aim of this study was to identify a peptide with improved tu...
متن کاملPractical dosimetry of peptide receptor radionuclide therapy with (90)Y-labeled somatostatin analogs.
The challenge for internal therapy is to deliver the highest possible dose to the tumor while sparing normal organs from damage. Currently, the potential risk of kidney and red marrow toxicity limits the amount of radioactivity that may be administered. An accurate dosimetry method that would provide reliable dose estimates to these critical organs and to tumors before therapy would allow the c...
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ژورنال
عنوان ژورنال: Clinical and Translational Imaging
سال: 2014
ISSN: 2281-5872,2281-7565
DOI: 10.1007/s40336-014-0054-2